A Novel Method for Modelling Cellular Response Genome Stress by Combined Gene- Environment Network (GEN) and Kinetic Theory Framework

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Qi, Jinpeng; Zhang, Qing; Qi, Jie


2014-08-24


Conference Material


19th IFAC World Congress, South Africa, 24/8/2014


1152-1157


Under acute Ion Radiation (IR) perturbation from external environment, a normal cell can trigger a series of cellular self-defensive mechanisms. To model the complicated Cellular Response Genome Stress (CRGS, for short), a novel method is proposed based on combined Gene-Environment Network (GEN) and Kinetic Theory of Active Particle (KTAP) framework. In this method, the integrated CRGS model is divided into three subsystems, and each subsystem is composed of different particles with different discrete states at molecular level. Then the dynamic kinetics of integrated CRGS is dealt as outcomes of complicated mutual interactions among molecular particles from different subsystems and external environment cofactors at systematic level. The simulation results show that our method is efficient to illustrate a series of cellular activities, including stochastic Double Strand Break (DSB) generation and repair, switch-like Ataxia Telangiectasia Mutated (ATM) activation, oscillating P53-MDM2 feedback loop as well, and helpful to analyze the capability of cellular self-defensive mechanism, as well as genome stability in response to different IR perturbation circumstances.


Elsevier


Health Informatics


EP145112


Conference Paper - Refereed


English


Qi, Jinpeng; Zhang, Qing; Qi, Jie. A Novel Method for Modelling Cellular Response Genome Stress by Combined Gene- Environment Network (GEN) and Kinetic Theory Framework. In: 19th IFAC World Congress; 24/8/2014; South Africa. Elsevier; 2014. 1152-1157. http://hdl.handle.net/102.100.100/94350?index=1



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