Modulating the microbiome and immune responses using whole plant fibre in synbiotic combination with fibre-digesting probiotic attenuates chronic colonic inflammation in spontaneous colitic mice model of IBD

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Shinde, Tanvi; Vemuri, Ravichandra; Shastri, Sonia; Perera, Agampodi; Gondalia, Shakuntla ORCID ID icon; Beale, David ORCID ID icon; Karpe, Avinash ORCID ID icon; Eri, Rajaraman; Stanley, Roger


2020-08-09


Journal Article


Nutrients


12


8


26


A probiotic and prebiotic food ingredient combination was tested for synergistic functioning in modulation of the colonic microbiome and remediation of the gastrointestinal immune and inflammatory responses in a spontaneous colitic mouse model. Bacillus coagulans MTCC5856 spores; with capability to metabolise complex plant polysaccharides; were supplemented with complex whole-plant prebiotic sugarcane fibre (PSCF).The combined and individual efficacies were tested for influencing the outcomes of chronic inflammation in Muc2 mutant colitic Winnie mice. The mice were fed normal chow diet supplemented with either ingredient or a combination for 21 days. Synbiotic combined supplementation ameliorated clinical symptoms and histological colonic damage scores more effectively than either B. coagulans or PSCF alone. PSCF and B. caogulans alone also induced considerable immunomodulatory effects. Synbiotic however was the most efficacious in modulating the overall immune profile compared to the unsupplemented Winnie-control. The augmented synbiotic effect could potentially be due to a combination of increased levels of fermentation products; direct immune-modulating abilities of the components; their capability to improve epithelial integrity and/or modulation of the microbiota. The beneficial effects of the supplementation with a complex plant fibre and a fibre-degrading probiotic parallel the effects seen in human microbiota with high plant fibre diets.


MDPI


Synbiotic; Prebiotic; Probiotic; IBD; Bacillus spores; whole plant sugarcane fibre; SCFAs; dysbiosis; gut microbiota


Nutrition and Dietetics not elsewhere classified


https://doi.org/10.3390/nu12082380


EP205167


Journal article - Refereed


English


Shinde, Tanvi; Vemuri, Ravichandra; Shastri, Sonia; Perera, Agampodi; Gondalia, Shakuntla; Beale, David; Karpe, Avinash; Eri, Rajaraman; Stanley, Roger. Modulating the microbiome and immune responses using whole plant fibre in synbiotic combination with fibre-digesting probiotic attenuates chronic colonic inflammation in spontaneous colitic mice model of IBD. Nutrients. 2020; 12(8):26. https://doi.org/10.3390/nu12082380



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