Catecholamines and Ca2+ mediate an increase in activity and reactive thiols of rat heart phosphofructokinase

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Clark, M. G.; Rattigan, S.; Patten, G. S.; Filsell, O. H.

Clark, M. G.; Rattigan, S.; Patten, G. S.; Filsell, O. H.


1987-03


Journal Article


Biochemical Journal


242


2


597-601


Catecholamines and Ca2+ mediate an increase in reactive-thiol status of phosphofructokinase, associated with an increase in activation of the enzyme. A correlation was observed between the number of reactive thiols and activation (r = 0.878; P less than 0.001) for 14 different treatments, with approx. 1 group per 85,000-Mr subunit becoming available over the range from the lowest to the highest state of activation.


Human Nutrition; Acylation Animals Calcium: *pharmacology Enzyme Activation: drug effects Epinephrine: *pharmacology Iodoacetates: metabolism Iodoacetic Acid Male Myocardium: *enzymology Phosphofructokinase-1: *metabolism Rats Rats, Inbred Strains Sulfhydryl Compounds: *metabolism Support, Non-U.S. Gov't


English


0264-6021


procite:a9b31aeb-ba65-4974-8e0f-19e2bc6d2482


Clark, M. G. ; Rattigan, S. ; Patten, G. S. ; Filsell, O. H. Catecholamines and Ca2+ mediate an increase in activity and reactive thiols of rat heart phosphofructokinase. Biochemical Journal. 1987-03; 242(2):597-601.



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